S4E6: Shella Keilholz - 静息态fMRI中无处不在的准周期模式

Neurosalience #S4E6: Shella Keilholz - 静息态fMRI中无处不在的准周期模式

今天，我们的嘉宾是 ShellaKeilholz。Keilholz 博士于1997年从密苏里科技大学获得物理学学士学位，2004年从弗吉尼亚大学获得工程物理学博士学位。之后，她在NIH的Alan Koretsky博士实验室做了博士后研究，并于2004年加入埃默里大学生物医学工程系成为一名教员。她现在是埃默里大学的正教授，并与佐治亚理工学院有密切的联系。

自2008年左右，她一直在发现静息态fMRI中的新的空间和时间模式。她是第一个识别出静息态时间序列中波浪式行为的空间传播的人，并在2011年首次提出“准周期模式”（quasi-periodic patterns, QPP）这一术语，以描述在大部分静息态信号中占据主导地位的整个大脑网络。最近，她和其他人描述了三种这样的模式，这些模式解释了大部分的差异。在这里，我们不仅讨论她的职业生涯，还深入探讨了这些准周期模式如何与持续被发现的静息态fMRI的多样化特征相融合。她已经表明，这些模式可能有一个中心驱动器，并且可能与血管运动、全局信号、唤醒状态和注意力等事物相关。总的来说，从基础神经生理学到认知，静息态fMRI中仍有更多信息有待挖掘，而 Shella 是领导这一努力的人之一。

这是一次非常精彩有趣的讨论。希望你喜欢它！

节目制作人：

Omer Faruk Gulban

Jeff Mentch

Neurosalience #S4E6 with Shella Keilholz -Ubiquitous quasi-periodic patterns in resting state fMRI

Today, our guest isShella Keilholz. Dr. Keilholz received her Bachelor's in Physics from MissouriUniversity of Science and Technology in 1997, and her PhD in EngineeringPhysics from the University of Virginia in 2004. She went on to a do a post-docat NIH in Dr. Alan Koretsky's lab and in 2004 joined the department ofBiomedical Engineering at Emory University as a faculty member. She is now afull professor at Emory University and also closely affiliated with GeorgiaTech.

Since around 2008 shehas been uncovering new spatial and temporal patterns in resting state fMRI.She was the first to identify spatial propagation of wave-like behavior in theresting state time series and in 2011 coined the term quasi-periodic patterns(QPP) to describe whole brain networks that dominate much of the resting statesignal. Recently, she and others have described three such patterns thataccount for most of the variance. Here we not only talk about her career butalso delve into how these quasi-periodic patterns mesh with the currentlandscape of diverse features of resting state fMRI that continue to be found.She has shown that these patterns may have a central driver and may relate tosuch things as vasomotion, global signal, arousal state, and attention. Ingeneral, there is much more information from basic neurophysiology to cognitionthat remains to be derived from resting state fMRI, and Shella is among thoseleading the effort.

This was an incrediblystimulating and fun discission. We hope you enjoy it!

Episode producers:OmerFaruk Gulban

Jeff Mentch